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Beckmann D, Romer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, … Pap T, Korb-Pap A 2021 Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. Nat Commun 12, 3624

Furlan AG, Spanou CES, Godwin ARF, Wohl AP, Zimmermann LA, Imhof T, Koch M, Baldock C, Sengle G 2021 A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix. FASEB J 35, e21353

Herrmann M, Diederichs S, Melnik S, Riegger J, Trivanović D, Li S, Jenei-Lanzl Z, Brenner RE, Huber-Lang M, Zaucke F, Schildberg FA, Grässel S. 2021 Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration. Front Bioeng Biotechnol. 8:624096

Izu Y, Adams SM, Connizzo BK, Beason DP, Soslowsky LJ, Koch M, Birk DE 2021 Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function. Matrix Biol 95, 52-67

Mahlich D, Glasmacher A, Muller I, Oppermann J, Grevenstein D, Eysel P, Heilig J, Wirth B, Zaucke F, Niehoff A 2021 Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee. Int J Mol Sci 22

Morcos Y, Lütke S, Tenbieg A, Hanisch FG, Hoffmann T, Keller T, Janoschek R, Niehoff A, Zaucke F, Dötsch J, Hucklenbruch-Rother E, Sengle G 2021 Sensitive asprosin detection in clinical samples reveals serum/ saliva correlation and indicates cartilage as source for serum asprosin. Sci Rep 12(1):1340.

Nuchel J, Tauber M, Nolte JL, Morgelin M, Turk C, Eckes B, Demetriades C, Plomann M 2021 An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Mol Cell 81, 3275-3293 e3212

Seifer P, Hay E, Fleischhauer L, Heilig J, Bloch W, Sonntag S, Shmerling D, Clausen-Schaumann H, Aszodi A, Niehoff A, Cohen-Solal M, Paulsson M, Wagener R, Zaucke F 2021 The Matrilin-3 T298M mutation predisposes for post-traumatic osteoarthritis in a knock-in mouse model. Osteoarthritis Cartilage 29(1):78-88.

Sohn R, Rösch G, Junker M, Meurer A, Zaucke F, Jenei-Lanzl Z. 2021 Adrenergic signalling in osteoarthritis. Cell Signal. 82:109948.

Vollersen N, Zhao W, Rolvien T, Lange F, Schmidt FN, Sonntag S, Shmerling D, von Kroge S, Stockhausen KE, Sharaf A, Schweizer M, Karsak M, Busse B, Bockamp E, Semler O, Amling M, Oheim R, Schinke T, Yorgan TA 2021 The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV. Bone Res. 9(1):48.


Auler A, Bergmeier V, Georgieva VS, Pitzler L, Frie C, Nüchel J, Eckes B, Hinz B, Brachvogel B 2020 miR-127-3p is an epigenetic activator of myofibroblast senescence situated within the miRNA enriched Dlk1-Dio3 imprinted domain on mouse chromosome 12.  J Invest Dermatol. [Epub ahead of print]

Etich J, Leßmeier L, Rehberg M, Sill H, Zaucke F, Netzer C, Semler O 2020 Osteogenesis imperfecta-pathophysiology and therapeutic options. Mol Cell Pediatr. 7(1):9.

Etich J, Rehberg M, Eckes B, Sengle G, Semler O, Zaucke F 2020 Signaling pathways affected by mutations causing osteogenesis imperfecta. Cell Signal. [Epub ahead of print]

Georgieva VS, Etich J, Bluhm B, Zhu M, Frie C, Wilson R, Zaucke F, Bateman J, Brachvogel B 2020 Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage. Int J Mol Sci 21(11):E4112.

Godmann L, Bollmann M, Korb-Pap A, König U, Sherwood J, Beckmann D, Mühlenberg K, Echtermeyer F, Whiteford J, De Rossi G, Pap T, Bertrand J 2020 Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling. Ann Rheum Dis. 79(4):481-489.

Hedderich J, El Bagdadi K, Angele P, Grässel S, Meurer A, Straub RH, Zaucke F, Jenei-Lanzl Z 2020 Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation. Int J Mol Sci 21(11):E3924.

Heilig J, Dietmar H, Brachvogel B, Paulsson M, Zaucke F, Niehoff A 2020 Collagen IX deficiency causes premature vascularization and ossification of murine femoral heads through an imbalance of pro- and antiangiogenic factors. Osteoarthritis Cartilage 28(7):988-999.

Huyghe A, Furlan G, Ozmadenci D, Galonska C, Charlton J, Gaume X, Combémorel N, Riemenschneider C, Allègre N, Zhang J, Wajda P, Rama N, Vieugué P, Durand I, Brevet M, Gadot N, Imhof T, Merrill BJ, Koch M, Mehlen P, Chazaud C, Meissner A, Lavial F 2020 Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signaling. Nat Cell Biol 22(4):389-400.

Köhler A, Mörgelin M, Gebauer JM, Öcal S, Imhof T, Koch M, Nagata K, Paulsson M, Aumailley M, Baumann U, Zaucke F, Sengle G. 2020 New specific HSP47 functions in collagen subfamily chaperoning. FASEB J. 34(9):12040-12052.

Li P, Fleischhauer L, Nicolae C, Prein C, Farkas Z, Saller MM, Prall WC, Wagener R, Heilig J, Niehoff A, Clausen-Schaumann H, Alberton P, Aszodi A 2020 Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis. Int J Mol Sci 21(2).

Rehberg M, Azim M, Martakis K, Winzenrieth R, Hoyer-Kuhn H, Schoenau E, Semler O, Duran I 2020 Bone microarchitecture assessed by trabecular bone score is independent of mobility level or height in pediatric patients with cerebral palsy. J Bone Miner Res. [Epub ahead of print]

Solomon-Degefa H, Gebauer JM, Jeffries CM, Bird LE, Baumann U, Svergun DI, Owens RJ, Werner JM, Paulsson M, Wagener R 2020 Structure and flexibility of the collagen VI α3 chain VWA domain array: Functional implications of myopathy causing mutations. J Biol Chem. 295(36):12755-12771.

van Dijk FS, Semler O, Etich J, Köhler A, Jimenez-Estrada JA, Bravenboer N, Claeys L, Riesebos E, Gegic S, Piersma SR, Jimenez CR, Waisfisz Q, Flores CL, Nevado J, Harsevoort AJ, Janus GJM, Franken AAM, van der Sar AM, Meijers-Heijboer H, Heath KE, Lapunzina P, Nikkels PGJ, Santen GWE, Nüchel J, Plomann M, Wagener R, Rehberg M, Hoyer-Kuhn H, Eekhoff EMW, Pals G, Mörgelin M, Newstead S, Wilson BT, Ruiz-Perez VL, Maugeri A, Netzer C, Zaucke F, Micha D. 2020 Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2. Am J Hum Genet. 107(5):989-999.

Westermann LM, Fleischhauer L, Vogel J, Jenei-Lanzl Z, Ludwig NF, Schau L, Morellini F, Baranowsky A, Yorgan TA, Di Lorenzo G, Schweizer M, de Souza Pinheiro B, Guarany NR, Sperb-Ludwig F, Visioli F, Oliveira Silva T, Soul J, Hendrickx G, Wiegert JS, Schwartz IVD, Clausen-Schaumann H, Zaucke F, Schinke T, Pohl S, Danyukova T. 2020 Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma. Dis Model Mech. 13(11).

Wirth B, Karakaya M, Kye MJ, Mendoza-Ferreira N 2020 Twenty-five years of spinal muscular atrophy research: from phenotype to genotype to therapy, and what comes next. Annu Rev Genomics Hum Genet [Epub ahead of print]


Bolduc V, Foley AR, Solomon-Degefa H, Sarathy A, Donkervoort S, Hu Y, Chen GS, Sizov K, Nalls M, Zhou H, Aguti S, Cummings BB, Lek M, Tukiainen T, Marshall JL, Regev O, Marek-Yagel D, Sarkozy A, Butterfield RJ, Jou C, Jimenez-Mallebrera C, Li Y1, Gartioux C, Mamchaoui K, Allamand V, Gualandi F, Ferlini A, Hanssen E; COL6A1 Intron 11 Study Group, Wilton SD, Lamandé SR, MacArthur DG, Wagener R, Muntoni F, Bönnemann CG 2019 A recurrent COL6A1 pseudoexon insertion causes muscular dystrophy and is effectively targeted by splice-correction therapies. JCI Insight 4(6).

Elezagic D, Mörgelin M, Hermes G, Hamprecht A, Sengle G, Lau D, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR 2019 Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) - potential in the prevention and treatment of septic arthritis. Osteoarthritis Cartilage 27(10):1564-1573.

Etich J, Koch M, Wagener R, Zaucke F, Fabri M, Brachvogel B 2019 Gene Expression Profiling of the Extracellular Matrix Signature in Macrophages of Different Activation Status: Relevance for Skin Wound Healing. Int J Mol Sci 20(20).

Feng C, Chan WCW, Lam Y, Wang X, Chen P, Niu B, Ng VCW, Yeo JC, Stricker S, Cheah KSE, Koch M, Mundlos S, Ng HH, Chan D 2019 Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes. Stem Cell Reports 13(4):713-729.

Heumüller SE, Talantikite M, Napoli M, Armengaud J, Mörgelin M, Hartmann U, Sengle G, Paulsson M, Moali C, Wagener R 2019 C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes. J Biol Chem 294(37):13769-13780.

Holzer T, Probst K, Etich J, Auler M, Georgieva VS, Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel J, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B 2019 Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases. J Cell Biol 218(6):1853-1870.

Hoyer-Kuhn H, Rehberg M, Netzer C, Schoenau E, Semler O 2019 Individualized treatment with denosumab in children with osteogenesis imperfecta - follow up of a trial cohort. Orphanet J Rare Dis 14(1):219.

Jenei-Lanzl Z, Meurer A, Zaucke F 2019 Interleukin-1β signaling in osteoarthritis - chondrocytes in focus. Cell Signal 53:212-223.

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Heumüller SE, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R 2019 Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc. 14(12):3395-3425.

Mohassel P, Liewluck T, Hu Y, Ezzo D, Ogata T, Saade D, Neuhaus S, Bolduc V, Zou Y, Donkervoort S, Medne L, Sumner CJ, Dyck PJB, Wierenga KJ, Tennekoon G, Finkel RS, Chen J, Winder TL, Staff NP, Foley AR, Koch M, Bönnemann CG 2019 Dominant collagen XII mutations cause a distal myopathy. Ann Clin Transl Neurol. 6(10):1980-1988.

Moosa S, Yamamoto GL, Garbes L, Keupp K, Beleza-Meireles A, Moreno CA, Valadares ER, de Sousa SB, Maia S, Saraiva J, Honjo RS, Kim CA, Cabral de Menezes H, Lausch E, Lorini PV, Lamounier A Jr, Carniero TCB, Giunta C, Rohrbach M, Janner M, Semler O, Beleggia F, Li Y, Yigit G, Reintjes N, Altmüller J, Nürnberg P, Cavalcanti DP, Zabel B, Warman ML, Bertola DR, Wollnik B, Netzer C 2019 Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta. Am J Hum Genet 105(4):836-843.

Rehberg M, Winzenrieth R, Hoyer-Kuhn H, Duran I, Schoenau E, Semler O 2018 TBS as a Tool to Differentiate the Impact of Antiresorptives onCortical and Trabecular Bone in Children With OsteogenesisImperfecta. J Clin Densitom 22(2):229-235.

Tonelotto V, Trapani V, Bretaud S, Heumüller SE, Wagener R, Ruggiero F, Bonaldo P 2019 Spatio-temporal expression and distribution of collagen VI during zebrafish development. Sci Rep 9:19851.

Üstün Y, Reibetanz M, Brachvogel B, Nischt R, Eckes B, Zigrino P, Krieg T 2019 Dual role of laminin‑511 in regulating melanocyte migration and differentiation. Matrix Biol 80:59-71.


Gebauer JM, Köhler A, Dietmar H, Gompert M, Neundorf I, Zaucke F, Koch M, Baumann U 2018 COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens. Sci Rep 8(1):17187

Neugebauer J, Heilig J, Hosseinibarkooie S, Ross BC, Mendoza-Ferreira N, Nolte F, Peters M, Hölker I, Hupperich K, Tschanz T, Grysko V, Zaucke F, Niehoff A, Wirth B 2018 Plastin 3 influences bone homeostasis through regulation of osteoclast activity. Hum Mol Genet 27(24):4249-426.