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2023

Beckmann D, Krause A, Hansen U, Kiener HP, Karonitsch T, Blüml S, Kremerskothen J, Pavenstädt H, Pap T, Korb-Pap A. Focal adhesion protein Lasp1 links the Arp2/3 complex to adherens junctions and promotes motility of arthritic fibroblast-like synoviocytes. Ann Rheum Dis. (2024 Feb 19:ard-2023)

Karonitsch T, Saferding V, Kieler M, von Dalwigk K, Tosevska A, Heller G, Dellinger M, Niederreiter B, Kartnig F, Steiner CW, Georgel P, Kiener HP, Smolen JS, Korb-Pap A, Bonelli M, Aletaha D, Blüml S. Amino Acids Fueling Fibroblast-Like Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration. Arthritis Rheumatol. (2023 Nov 20) 

Zehner M, Alt M, Ashurov A, Goldsmith JA, Spies R, Weiler N, Lerma J, Gieselmann L, Stöhr D, Gruell H, Schultz EP, Kreer C, Schlachter L, Janicki H, Laib Sampaio K, Stegmann C, Nemetchek MD, Dähling S, Ullrich L, Dittmer U, Witzke O, Koch M, Ryckman BJ, Lotfi R, McLellan JS, Krawczyk A, Sinzger C, Klein F. Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer. Immunity. (2023 Nov 14)

Simonis A, Kreer C, Albus A, Rox K, Yuan B, Holzmann D, Wilms JA, Zuber S, Kottege L, Winter S, Meyer M, Schmitt K, Gruell H, Theobald SJ, Hellmann AM, Meyer C, Ercanoglu MS, Cramer N, Munder A, Hallek M, Fätkenheuer G, Koch M, Seifert H, Rietschel E, Marlovits TC, van Koningsbruggen-Rietschel S, Klein F, Rybniker J. Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa. Cell. (2023 Nov 9)

Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, Bock F. The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. J Mol Cell Biol. (2023 Oct 27)

Fernandes SA., Angelidaki D-D., Nüchel J., Pan J., Gollwitzer P., Elkis Y., Artoni F., Wilhelm S., Kovacevic-Sarmiento M., and Demetriades C., Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability. bioRxiv. (2023 October 3)

Pektas HK, Demidov Y, Ahvan A, Abie N, Georgieva VS, Chen S, Farè S, Brachvogel B, Mathur S, Maleki H. MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration. ACS Mater Au. (2023 Sep 8)

Alan R. F. Godwin , Rana Dajani, Xinyang Zhang, Jennifer Thomson, David F. Holmes, Christin S. Adamo , Gerhard Sengle, Michael J. Sherratt , Alan M. Roseman  & Clair Baldock (20 April 2023) Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site

Liphardt AM, Godonou ET, Dreiner M, Mündermann A, Tascilar K, Djalal N, Heer M, Schett G, Zaucke F, Niehoff A. Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals. Osteoarthritis Cartilage. (2023 Nov 19)

Sawant M, Wang F, Koester J, Niehoff A, Nava MM, Lundgren-Akerlund E, Gullberg D, Leitinger B, Wickström S, Eckes B, Krieg T. Ablation of integrin-mediated cell-collagen communication alleviates fibrosis. Ann Rheum Dis. (2023 Nov)

Priya A, Antoine-Bally S, Macé AS, Monteiro P, Sabatet V, Remy D, Dingli F, Loew D, Demetriades C, Gautreau AM, Chavrier P. Codependencies of mTORC1 signaling and endolysosomal actin structures. Sci Adv. (2023 Sep 15)

Freiburg, C.D., Solomon-Degefa, H., Freiburg, P., Mörgelin, M., Bolduc, V., Schmitz. S., Ala, P., Muntoni, F., Behrmann, E., Bönnemann, C.G., Schiavinato, A., Paulsson, M., and Wagener, R. (2023) The UCMD causing COL6A1 (c.930+189C>T) intron mutation leads to the secretion and aggregation of single mutated collagen VI a1 chains. Human Mutation, (2023 Sept. 6)

Nicastro R, Brohée L, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nat Cell Biol. (2023 Sep)

Rösch G, Zaucke F, Jenei-Lanzl Z. Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis. Am J Physiol Cell Physiol. (2023 Aug 1)

Brenneis M, Junker M, Sohn R, Braun S, Ehnert M, Zaucke F, Jenei-Lanzl Z, Meurer A. Patellar malalignment correlates with increased pain and increased synovial stress hormone levels-A cross-sectional study. PLoS One. (2023 Jul 27)

Zhu M, Metzen F, Hopkinson M, Betz J, Heilig J, Sodhi J, Imhof T, Niehoff A, Birk DE, Izu Y, Krüger M, Pitsillides AA, Altmüller J, van Osch GJVM, Straub V, Schreiber G, Paulsson MKoch M, Brachvogel B (28 June 2023). Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation. iScience.

Julia EtichOliver Semler, Nicola L Stevenson, Alice Stephan, Roberta Besio, Nadia Garibaldi, Nadine Reintjes, Claudia Dafinger, Max Christoph Liebau, Ulrich Baumann, Matthias Mörgelin, Antonella Forlino, David J Stephens, Christian Netzer, Frank ZauckeMirko Rehberg (9 June 2023) TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta

Anders Karlsen, Ching-Yan Chloe! Yeung, Peter Schjerling, Linda Denz, Christian Hoegsbjerg, Jens R. Jakobsen, Michael R. Krogsgaard, Manuel Koch, Stefano Schiaffino, Michael Kjaer and Abigail L. Mackey (Apr 15 2023) Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing

Ermanoska B, Asselbergh B, Morant L, Petrovic-Erfurth ML, Hosseinibarkooie S, Leitão-Gonçalves R, Almeida-Souza L, Bervoets S, Sun L, Lee L, Atkinson D, Khanghahi A, Tournev I, Callaerts P, Verstreken P, Yang XL, Wirth B, Rodal AA, Timmerman V, Goode BL, Godenschwege TA, Jordanova A. Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling. Nat Commun. (2023 Mar 8)

Meier M, Gupta M, Akgül S, McDougall M, Imhof T, Nikodemus D, Reuten R, Moya-Torres A, To V, Ferens F, Heide F, Padilla-Meier GP, Kukura P, Huang W, Gerisch B, Mörgelin M, Poole K, Antebi A, Koch M, Stetefeld J. The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation. Nat Commun. (2023 Mar 3)

Strathmann EA, Hölker I, Tschernoster N, Hosseinibarkooie S, Come J, Martinat C, Altmüller J, Wirth B. Epigenetic regulation of plastin 3 expression by the macrosatellite DXZ4 and the transcriptional regulator CHD4. Am J Hum Genet. (2023 Mar 2)

Pavinato L, Delle Vedove A, Carli D, Ferrero M, Carestiato S, Howe JL, Agolini E, Coviello DA, van de Laar I, Au PYB, Di Gregorio E, Fabbiani A, Croci S, Mencarelli MA, Bruno LP, Renieri A, Veltra D, Sofocleous C, Faivre L, Mazel B, Safraou H, Denommé-Pichon AS, van Slegtenhorst MA, Giesbertz N, van Jaarsveld RH, Childers A, Rogers RC, Novelli A, De Rubeis S, Buxbaum JD, Scherer SW, Ferrero GB, Wirth B, Brusco A. CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD. Brain. (2023 Feb 13)

Jakobsen JR, Mackey AL, Koch M, Imhof T, Hannibal J, Kjaer M, Krogsgaard MR. Larger interface area at the human myotendinous junction in type 1 compared with type 2 muscle fibers. Scand J Med Sci Sports. (2023 Feb)

Rapp AE, Zaucke F. Cartilage extracellular matrix-derived matrikines in osteoarthritis. Am J Physiol Cell Physiol. (2023 Feb 1)

Esho, T.; Kobbe, B.; Tufa, S.F.; Keene, D.R.; Paulsson, M.; Wagener, R. The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form Anchoring Cords in the Absence of AMACO at the Dermal–Epidermal Junction of Mouse Skin. Int. J. Mol. Sci. (2023)

Spanou CES, Wohl AP, Doherr S, Correns A, Sonntag N, Lütke S, Mörgelin M, Imhof T, Gebauer JM, Baumann U, Grobe K, Koch M, Sengle G. Targeting of bone morphogenetic protein complexes to heparin/heparan sulfate glycosaminoglycans in bioactive conformation. FASEB J. (2023 Jan)