DFG Research Unit FOR2722

 

Novel molecular determinants for musculoskeletal extracellular matrix homeostasis - a systemic approach

 

Bent Brachvogel's group identifies the mitochondrial respiratory chain as a new therapeutic target for treating a defective extracellular matrix in degenerative cartilage disease:
Dysfunction in the mitochondrial respiration leads to cartilage degenerative diseases

Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage

05.03.2021

Interview with Honorary Doctor Mats Paulsson

Please visit University of Oulu's official Spotify channel

21.01.2021

New publication by project D1

The research unit FOR2722 congratulates Prof. Brunhilde Wirth for her outstanding detective work in science.

VWA1 identified as a new disease gene for neuromyopathy: An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy

18.01.2021

New publication by projects B1 and D2

The Matrilin-3 T298M mutation predisposes for post-traumatic osteoarthritis in a knock-in mouse model

14.10.2020

New publication by project D2

Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2

16.09.2020

New publication by project D2

New specific HSP47 functions in collagen subfamily chaperoning

Novel structure-function relationships of myopathy patient mutations in collagen VI identified by Mats Paulsson and Raimund Wagner of the Research Unit. Results shed light on possible myopathy mechanisms.

 

03.06.2020

New publication by project D2:

Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients With Cerebral Palsy

19.05.2020

New publication by project D1:

Twenty-Five Years of Spinal Muscular Atrophy Research: From Phenotype to Genotype to Therapy, and What Comes Next

04.02.2020

The University of Oulu will confer an honorary doctorate to FOR2722 member Prof. Mats Paulsson

The research unit FOR2722 congratulates Prof. Mats Paulsson for receiving the honorary degree of the University of Oulu.

To acknowledge his longtime commitment and outstanding research on extracellular matrix the Faculty of Biochemistry and Molecular Medicine will confer Prof. Paulsson the highest honor granted by the University of Oulu.

14.11.2019

New publications by project D2:

Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta

Individualized treatment with denosumab in children with osteogenesis imperfecta - follow up of a trial cohort

FOR 2722 researchers resolve the in vivo biogenesis of endotrophin, a proteolytic fragment of collagen VI that has been proposed to act as an adipokine.

This article has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Peter Torzilli.

The state government of North Rhine-Westphalia awarded the NRW-Innovation prize 2019 to Prof. Dr. Brunhilde Wirth for her groundbreaking research on spinal muscular dystrophy.

The research unit FOR2722 congratulates Prof. Dr. Brunhilde Wirth and wishes her every success for her future research.